PXD025933

PXD025933 is an original dataset announced via ProteomeXchange.

Title	Proteomics characterisation of induced pluripotent stem cells and cortical brain organoids.
Description	A method was developed to reproducibly produce neural retina and cortical brain regions from confluent cultures of stem cells. The spontaneously generated cortical organoids were isolated and cultured in suspension conditions for maturation. Proteomic analysis of both the original induced pluripotent stem cells and the cortical organoids demonstrated the increased presence of synaptic components, indicating maturity.
HostingRepository	PRIDE
AnnounceDate	2022-05-06
AnnouncementXML	Submission_2022-05-09_05:34:46.951.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD025933
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mark Graham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-11 02:39:20	ID requested
1	2022-05-06 10:51:24	announced
⏵ 2	2022-05-09 05:34:47	announced	2022-05-09: Updated publication reference for PubMed record(s): 35523177.

Fernando M, Lee S, Wark JR, Xiao D, Lim BY, O'Hara-Wright M, Kim HJ, Smith GC, Wong T, Teber ET, Ali RR, Yang P, Graham ME, Gonzalez-Cordero A, Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin. Stem Cell Reports, 17(6):1476-1492(2022) [pubmed]

submitter keyword: Organoid, brain, cortical, neural retina, stem cell, pluripotent, proteomics

Mark Evan Graham
contact affiliation	Synapse Proteomics, Children's Medical Research Insitute, The University of Sydney, Australia
contact email	mgraham@cmri.org.au
lab head
Mark Graham
contact affiliation	Children's Medical Research Institute
contact email	mgraham@cmri.org.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD025933

PRIDE project URI

• PRIDE
  1. PXD025933
     1. Label: PRIDE project
     2. Name: Proteomics characterisation of induced pluripotent stem cells and cortical brain organoids.