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PXD025904

PXD025904 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystematic analysis of the protein binding networks of TMEM43 and its S358L mutation
DescriptionArrhythmogenic right ventricular cardiomyopathy (ARVC) is a severe heart muscle disease leading to sudden cardiac death. The S358L mutation of TMEM43 was first identified in 15 Newfoundland families of ARVC. This mutation is associated with ARVC5, a severe subtype of ARVC with full penetrance and a high percentage of death in patients. Although some studies have revealed that the TMEM43 mutant alters the localization of cardiac proteins, the interaction protein networks of TMEM43 and how the S358L mutation influences the interaction in ARVC remain to be explored. Thus We analyzed the binding partners of TMEM43 and determined the differential interaction proteins of TMEM43 upon S358L mutation.
HostingRepositoryiProX
AnnounceDate2021-05-10
AnnouncementXMLSubmission_2021-05-09_21:13:05.668.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYingsi Lu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-09 21:11:08ID requested
12021-05-09 21:13:06announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: ARVC,heart,IP-MS
Contact List
Chengming Zhu
contact affiliationThe Seventh Affiliated Hospital, Sun Yat-sen University
contact emailzhuchm3@mail.sysu.edu.cn
lab head
Yingsi Lu
contact affiliationThe Seventh Affiliated Hospital, Sun Yat-sen University
contact emailluys@mail2.sysu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI