PXD025837

PXD025837 is an original dataset announced via ProteomeXchange.

Title	Bone marrow-selected antigen specific regulatory B cells
Description	Autoimmunity is often regarded as pathogenic, but this view has gradually shifted over time. Based on insights from thymus selection, T cells are now known to be selected by self-antigens and positive selection in the thymus medulla leads to regulatory functions. B cells are selected in the bone marrow and the fundamental question is whether self-antigens in the bone marrow select antigen specific regulatory B cells. In this work, we show that B cells are indeed selected for proteins expressed in the bone marrow and develop into cells with regulatory function bearing distinct phenotypic fingerprint. Collagen type II specific regulatory B cells trigger the expansion of antigen specific regulatory T cells and protect against development of tissue specific autoimmune inflammation. These antigen specific regulatory B cells constitute a sizeable fraction of the normal B cell repertoire in both mice and humans.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:00:06.567.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Beusch
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-06 07:18:30	ID requested
1	2023-08-13 07:49:34	announced
⏵ 2	2024-10-22 06:00:06	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Breg,LC-MS/MS, FACS, Mouse

Rikard Holmdahl
contact affiliation	Division of Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute, Sweden
contact email	rikard.holmdahl@ki.se
lab head
Christian Beusch
contact affiliation	Division of Chemistry I Department of Medical Biochemistry & Biophysics Karolinska Institutet
contact email	christian.beusch@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD025837

PRIDE project URI

• PRIDE
  1. PXD025837
     1. Label: PRIDE project
     2. Name: Bone marrow-selected antigen specific regulatory B cells