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PXD025764

PXD025764 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe impact of Zika virus exposure on the placental proteomic profile
DescriptionZika virus (ZIKV) infection has caused severe unexpected clinical outcomes in neonates and adults during the recent outbreak in Latin America, particularly in Brazil. Congenital malformations associated with ZIKV have been frequently reported; nevertheless, the mechanism of vertical transmission and the involvement of placental cells remains unclear. In this study, we applied quantitative proteomics analysis in a floating explant model of chorionic villi of human placental tissues incubated with ZIKV and with ZIKV pre-adsorbed with anti-ZIKV envelope protein. The regulation of specific proteins was measured using immunofluorescence and immunoperoxidase assays. Altered levels of proteins were involved in cell proliferation, apoptosis, inflammatory processes, and the integrin-cytoskeleton complex. Antibody-opsonized ZIKV particles differentially modulated the pattern of protein expression in placental cells; this phenomenon may play a pivotal role in determining the course of infection and the role of mixed infections. These data fill gaps in our understanding of ZIKV in the placenta and help identify infection control targets.
HostingRepositoryPRIDE
AnnounceDate2021-12-30
AnnouncementXMLSubmission_2021-12-30_14:20:38.779.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGiuseppe Palmisano
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-03 22:52:27ID requested
12021-12-30 14:20:39announced
Publication List
Rosa-Fernandes L, Bandeira C, Pour SZ, Benedetti VF, Ferreira D, Lorenzon AR, Moreli JB, Marinho CRF, Larsen MR, Zanotto P, Palmisano G, Bevilacqua E, The impact of Zika virus exposure on the placental proteomic profile. Biochim Biophys Acta Mol Basis Dis, 1868(1):166270(2022) [pubmed]
Keyword List
submitter keyword: Zika virus, proteomics, antibody opsonization, placenta, cell death
Contact List
Estela M. A. F. Bevilacqua
contact affiliationInstitute of Biomedical Sciences, Department of Cell and Developmental Biology, University of São Paulo, 05508-000 São Paulo, SP, Brazil.
contact emailbevilacq@usp.br
lab head
Giuseppe Palmisano
contact affiliationUniversity of Sao Paulo
contact emailpalmisano.gp@gmail.com
dataset submitter
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Dataset FTP location
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