PXD025753 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | MDA-MB-231 MS analysis of ISGylome, GDI2 interactome and total proteome changes in different ISGylation models |
Description | Analysis of ISG15 conjugation (Isgylation)role as driver of poor prognosis in non HER2+ breast cancer tumours. The project includes an analysis of total proteome and ISGylome characterization of MDA-MB-231 cells, wild-type or knock-out for the ISGyltaion associated genes, ISG15, UBE2L6 and USP18. Additionally interactome analysis of the ISGylation target GDI2 was perfored in the same lines. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-03 |
AnnouncementXML | Submission_2021-11-03_05:52:02.252.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alfonso Bolado |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-05-02 23:34:07 | ID requested | |
⏵ 1 | 2021-11-03 05:52:03 | announced | |
Publication List
Bolado-Carrancio A, Lee M, Ewing A, Muir M, Macleod KG, Gallagher WM, Nguyen LK, Carragher NO, Semple CA, Brunton VG, Caswell PT, von Kriegsheim A, ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling. Oncogene, 40(44):6235-6247(2021) [pubmed] |
Keyword List
submitter keyword: ISG15, Breast cancer, GDI2, EGFR recycling |
Contact List
Alexander von Kriegsheim |
contact affiliation | Edinburgh Cancer Research Centre Principal investigator and Mass Spectrometry Facility Manager |
contact email | Alex.VonKriegsheim@igmm.ed.ac.uk |
lab head | |
Alfonso Bolado |
contact affiliation | University of Edinburgh |
contact email | Alfonso.Bolado@igmm.ed.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD025753 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025753
- Label: PRIDE project
- Name: MDA-MB-231 MS analysis of ISGylome, GDI2 interactome and total proteome changes in different ISGylation models