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PXD025716

PXD025716 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUpstream open reading frames regulate proto-oncogene translation and encode HLA-presented immunogenic tumor antigens
DescriptionUpstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leucocyte antigen (HLA)-presented peptides and suggest their potential role in cancer cell development and survival. However, it is so far unclear if uORF-encoded peptides could serve as tumor-associated antigen targets and thus also play a role in cancer immune surveillance. Combining mass spectrometry-based immunopeptidome analysis in primary tumor and healthy tissues and evaluation of proto-oncogene-associated uORF-mediated translational control we here identified a panel of HLA-presented tumor-associated uORF-derived antigens. These uORF-derived tumor antigens were further shown to induce multifunctional antigen-specific T cells, validating their suitability as antigen targets for T cell-based cancer immunotherapy. Our data further unravel the role of uORF-encoded peptides in malignant disease, suggesting uORF-derived tumor-associated antigens as targets for anti-cancer immune surveillance and immunotherapy development.
HostingRepositoryPRIDE
AnnounceDate2022-05-27
AnnouncementXMLSubmission_2022-05-27_05:08:32.278.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnnika Nelde
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion Lumos; LTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-29 10:50:15ID requested
12022-05-27 05:08:33announced
Publication List
Nelde A, Fl, ö, totto L, J, ü, rgens L, Szymik L, Hubert E, Bauer J, Schliemann C, Kessler T, Lenz G, Rammensee HG, Walz JS, Wethmar K, Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens. Cell Mol Life Sci, 79(3):171(2022) [pubmed]
Keyword List
submitter keyword: uORF, cancer, immunotherapy, immunopeptidomics, HLA peptides
Contact List
Juliane S. Walz
contact affiliationClinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany
contact emailjuliane.walz@med.uni-tuebingen.de
lab head
Annika Nelde
contact affiliationClinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Germany
contact emailannika.nelde@uni-tuebingen.de
dataset submitter
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