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PXD025639

PXD025639 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSulforaphane suppresses metastasis of breast cancer cells by targeting RAF/MEK/ERK pathway to inhibit actin stress fiber formation
DescriptionSFN, including its two isomers of R-SFN and S-SFN, significantly inhibited TGF-1-induced migration and invasion in MDA-MB-231 cells. Proteomic and phosphoproteomic analysis showed that SFN affected the formation of cytoskeleton. Subsequent experiments confirmed that SFN significantly inhibited TGF-1-induced actin stress fiber formation and the expression of actin stress fiber formation-associated proteins, including paxillin, IQGAP1, FAK, PAK2, and ROCK.
HostingRepositoryPRIDE
AnnounceDate2022-05-20
AnnouncementXMLSubmission_2022-05-19_23:38:05.739.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJing Liu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-26 03:20:01ID requested
12022-05-19 23:38:06announced
Publication List
Zhang Y, Lu Q, Li N, Xu M, Miyamoto T, Liu J, Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ Breast Cancer, 8(1):40(2022) [pubmed]
Keyword List
submitter keyword: Human, MDA-MB-231 cells, Sulforaphane, actin stress fiber formation
Contact List
Jing Liu
contact affiliationDalian Medical University
contact emailliujing8166@163.com
lab head
Jing Liu
contact affiliationDalian Medical University
contact emailliujing8166@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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