PXD025639

PXD025639 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Sulforaphane suppresses metastasis of breast cancer cells by targeting RAF/MEK/ERK pathway to inhibit actin stress fiber formation
Description	SFN, including its two isomers of R-SFN and S-SFN, significantly inhibited TGF-1-induced migration and invasion in MDA-MB-231 cells. Proteomic and phosphoproteomic analysis showed that SFN affected the formation of cytoskeleton. Subsequent experiments confirmed that SFN significantly inhibited TGF-1-induced actin stress fiber formation and the expression of actin stress fiber formation-associated proteins, including paxillin, IQGAP1, FAK, PAK2, and ROCK.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-19_23:38:05.739.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jing Liu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-26 03:20:01	ID requested
⏵ 1	2022-05-19 23:38:06	announced

Publication List

Zhang Y, Lu Q, Li N, Xu M, Miyamoto T, Liu J, Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ Breast Cancer, 8(1):40(2022) [pubmed]

Zhang Y, Lu Q, Li N, Xu M, Miyamoto T, Liu J, Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ Breast Cancer, 8(1):40(2022) [pubmed]

Keyword List

submitter keyword: Human, MDA-MB-231 cells, Sulforaphane, actin stress fiber formation

submitter keyword: Human, MDA-MB-231 cells, Sulforaphane, actin stress fiber formation

Contact List

Jing Liu
contact affiliation	Dalian Medical University
contact email	liujing8166@163.com
lab head
Jing Liu
contact affiliation	Dalian Medical University
contact email	liujing8166@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD025639
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD025639

PRIDE project URI

Repository Record List

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