PXD025639 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Sulforaphane suppresses metastasis of breast cancer cells by targeting RAF/MEK/ERK pathway to inhibit actin stress fiber formation |
Description | SFN, including its two isomers of R-SFN and S-SFN, significantly inhibited TGF-1-induced migration and invasion in MDA-MB-231 cells. Proteomic and phosphoproteomic analysis showed that SFN affected the formation of cytoskeleton. Subsequent experiments confirmed that SFN significantly inhibited TGF-1-induced actin stress fiber formation and the expression of actin stress fiber formation-associated proteins, including paxillin, IQGAP1, FAK, PAK2, and ROCK. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-20 |
AnnouncementXML | Submission_2022-05-19_23:38:05.739.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jing Liu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-26 03:20:01 | ID requested | |
⏵ 1 | 2022-05-19 23:38:06 | announced | |
Publication List
Zhang Y, Lu Q, Li N, Xu M, Miyamoto T, Liu J, Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ Breast Cancer, 8(1):40(2022) [pubmed] |
Keyword List
submitter keyword: Human, MDA-MB-231 cells, Sulforaphane, actin stress fiber formation |
Contact List
Jing Liu |
contact affiliation | Dalian Medical University |
contact email | liujing8166@163.com |
lab head | |
Jing Liu |
contact affiliation | Dalian Medical University |
contact email | liujing8166@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025639
- Label: PRIDE project
- Name: Sulforaphane suppresses metastasis of breast cancer cells by targeting RAF/MEK/ERK pathway to inhibit actin stress fiber formation