PXD025555

PXD025555 is an original dataset announced via ProteomeXchange.

Title	Hyperphosphorylation of sarcomeric proteins in heart failure with preserved ejection fraction: selective reversal of PKC hyperactivity by cell therapy
Description	Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca2+-sensitivity and mechanosensing. Treatment with cardiosphere-derived cells (CDCs) restores normal diastolic function, attenuates fibrosis and inflammation, and improves survival in a rat HFpEF model. Here, we quantified the phosphorylation changes that underlie HFpEF and those reversed by CDC therapy, with a focus on the sarcomeric subproteome.
HostingRepository	PRIDE
AnnounceDate	2022-04-23
AnnouncementXML	Submission_2022-04-23_03:45:22.608.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vidya Venkatraman
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-22 04:09:34	ID requested
⏵ 1	2022-04-23 03:45:23	announced

Soetkamp D, Gallet R, Parker SJ, Holewinski R, Venkatraman V, Peck K, Goldhaber JI, Marb, á, n E, Van Eyk JE, Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure. Circ Res, 129(12):1125-1140(2021) [pubmed]

submitter keyword: Heart failure with preserved ejection fraction (HFpEF)

Diastolic dysfunction

Myofilament phosphorylation, Cardiosphere-Derived Cell (CDC), Protein kinase C (PKC)

Dr. Jennifer Van Eyk
contact affiliation	Director, Advanced Clinical Biosystems Research Institute, Cedars-Sinai Medical Center
contact email	jennifer.vaneyk@cshs.org
lab head
Vidya Venkatraman
contact affiliation	Cedars-Sinai Medical Center
contact email	vidya.venkatraman@cshs.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD025555

PRIDE project URI

• PRIDE
  1. PXD025555
     1. Label: PRIDE project
     2. Name: Hyperphosphorylation of sarcomeric proteins in heart failure with preserved ejection fraction: selective reversal of PKC hyperactivity by cell therapy