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PXD025551

PXD025551 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative global Proteome and Phosphorylome Analyses Reveal Potential Biomarkers in Kidney Cancer
DescriptionNowadays, high-throughput quantitative proteomic and transcriptomic approaches have been widely used for exploring molecular mechanisms and acquiring biomarkers for cancers. Our study aims to illuminate the multi-dimensional molecular mechanisms underlying renal cell carcinoma via investigating the quantitative global proteome and the profile of phosphorylation. A total of 5428 proteins and 8632 phosphorylation sites were quantified in RCC tissues, with 709 proteins and 649 phosphorylation sites changing in expression compared with matched adjacent non-tumor tissues. These differentially expressed proteins were mainly involved in the metabolic process terms involving glycolysis pathway, oxidative phosphorylation and fatty acid metabolism which had been considered to be a potential mechanism of RCC progression. Moreover, phosphorylation analysis indicated that these up-regulated phosphorylated proteins were implicated in glucagon signaling pathway and cholesterol metabolism, while the down-regulated phosphorylation proteins were predominantly involved in glycolysis, pentose phosphate pathway, carbon metabolism and biosynthesis of amino acids. In addition, we also found several new candidate proteins such as CD14, MPO, NCF2, SOD2, PARP1 up-regulated and MUT, ACADM, PCK1 down-regulated in RCC, which might be recognized as new biomarkers for RCC. These findings could broaden our insight into the underlying molecular mechanisms of RCC and acquire biomarker candidates for the treatment of RCC.
HostingRepositoryPRIDE
AnnounceDate2022-02-17
AnnouncementXMLSubmission_2022-02-17_00:48:31.102.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitteryuanlei chen
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-22 00:33:02ID requested
12022-02-17 00:48:31announced
Publication List
Xu L, Lu Z, Yu S, Li G, Chen Y, Quantitative global proteome and phosphorylome analyses reveal potential biomarkers in kidney cancer. Oncol Rep, 46(5):(2021) [pubmed]
Keyword List
submitter keyword: Renal cell carcinoma
Proteomes
Phosphorylomes
Biomarkers
Pathways
Contact List
Yuanlei chen
contact affiliationSir run run shaw hospital
contact email610819633@qq.com
lab head
yuanlei chen
contact affiliationsir run run shaw hospital
contact email610819633@qq.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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