PXD025551

PXD025551 is an original dataset announced via ProteomeXchange.

Title	Quantitative global Proteome and Phosphorylome Analyses Reveal Potential Biomarkers in Kidney Cancer
Description	Nowadays, high-throughput quantitative proteomic and transcriptomic approaches have been widely used for exploring molecular mechanisms and acquiring biomarkers for cancers. Our study aims to illuminate the multi-dimensional molecular mechanisms underlying renal cell carcinoma via investigating the quantitative global proteome and the profile of phosphorylation. A total of 5428 proteins and 8632 phosphorylation sites were quantified in RCC tissues, with 709 proteins and 649 phosphorylation sites changing in expression compared with matched adjacent non-tumor tissues. These differentially expressed proteins were mainly involved in the metabolic process terms involving glycolysis pathway, oxidative phosphorylation and fatty acid metabolism which had been considered to be a potential mechanism of RCC progression. Moreover, phosphorylation analysis indicated that these up-regulated phosphorylated proteins were implicated in glucagon signaling pathway and cholesterol metabolism, while the down-regulated phosphorylation proteins were predominantly involved in glycolysis, pentose phosphate pathway, carbon metabolism and biosynthesis of amino acids. In addition, we also found several new candidate proteins such as CD14, MPO, NCF2, SOD2, PARP1 up-regulated and MUT, ACADM, PCK1 down-regulated in RCC, which might be recognized as new biomarkers for RCC. These findings could broaden our insight into the underlying molecular mechanisms of RCC and acquire biomarker candidates for the treatment of RCC.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_00:48:31.102.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yuanlei chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-22 00:33:02	ID requested
⏵ 1	2022-02-17 00:48:31	announced

Xu L, Lu Z, Yu S, Li G, Chen Y, Quantitative global proteome and phosphorylome analyses reveal potential biomarkers in kidney cancer. Oncol Rep, 46(5):(2021) [pubmed]

submitter keyword: Renal cell carcinoma

Proteomes

Phosphorylomes

Biomarkers

Pathways

Yuanlei chen
contact affiliation	Sir run run shaw hospital
contact email	610819633@qq.com
lab head
yuanlei chen
contact affiliation	sir run run shaw hospital
contact email	610819633@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD025551

PRIDE project URI

• PRIDE
  1. PXD025551
     1. Label: PRIDE project
     2. Name: Quantitative global Proteome and Phosphorylome Analyses Reveal Potential Biomarkers in Kidney Cancer