PXD025519

PXD025519 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomics of paired human vocal fold and oral mucosa tissue
Description	This dataset brief is about the descriptive proteomic comparison of human oral mucosa and vocal fold tissues by high-resolution mass spectrometry (CID-MS/MS). The vast majority of voice disorders is associated with changes of the unique but delicate tissue of the human vocal folds, wheras the ability to develop new effective treatment methods is significantly limited by the physical inaccessibility and the extremely rare occasion to gather healthy tissue biopsies. Therefore, oral mucosa reached specific interest for laryngological research, as the tissue harvesting process is less invasive and accompanied with faster healing and less scarring. Proteomic analysis of both tissues will provide a fundamental laryngological resource for the research community. Our study identifies a total of 1575 proteins detected within both tissues that are highly consistent in several crucial biological processes, cellular components, and molecular functions.
HostingRepository	PRIDE
AnnounceDate	2021-12-30
AnnouncementXML	Submission_2021-12-30_14:23:09.093.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Barbara Darnhofer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-21 02:43:07	ID requested
⏵ 1	2021-12-30 14:23:09	announced

Grossmann T, Darnhofer B, Birner-Gruenberger R, Kirsch A, Gugatschka M, Descriptive proteomics of paired human vocal fold and buccal mucosa tissue. Proteomics Clin Appl, 16(2):e2100050(2022) [pubmed]

submitter keyword: comparative proteomics, human tissue, oral mucosa, vocal folds

ruth birner-gruenberger
contact affiliation	Ruth Birner-Gruenberger, Ph.D. Full Professor for Analytical Chemistry Vienna University of Technology Institute of Chemical Technologies and Analytics Getreidemarkt 9/E164 A-1060 Vienna Austria Associate Professor for Biochemistry Medical University of Graz Diagnostic and Research Institute of Pathology Stiftingtalstrasse 24 A-8010 Graz Austria
contact email	ruth.birner-gruenberger@tuwien.ac.at
lab head
Barbara Darnhofer
contact affiliation	Omics Center Graz
contact email	barbara.darnhofer@klinikum-graz.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/12/PXD025519

PRIDE project URI

• PRIDE
  1. PXD025519
     1. Label: PRIDE project
     2. Name: Comparative proteomics of paired human vocal fold and oral mucosa tissue