PXD025472

PXD025472 is an original dataset announced via ProteomeXchange.

Title	C. elegans provide "milk" for their young
Description	The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signaling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-reproductive animals continues, supported by destructive repurposing of intestinal biomass that contributes to senescence. Post-reproductive mothers vent this yolk which can be consumed by larvae and promotes their growth. This implies that later yolk production is not futile; instead vented yolk functions similarly to milk. Moreover, yolk venting is promoted by IIS. That this process is promoted by IIS provides new insights into how and why IIS shortens lifespan in C. elegans. Fully-fed d4 hermaphrodites were allowed to vent for 30 min, and vented proteins analysed against excretory/secretory products collected for L3 larvae as a negative control.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_00:41:27.492.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Graham Taylor
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-19 06:33:58	ID requested
⏵ 1	2022-02-17 00:41:28	announced

Kern CC, Townsend S, Salzmann A, Rendell NB, Taylor GW, Comisel RM, Foukas LC, B, ä, hler J, Gems D, C. elegans feed yolk to their young in a form of primitive lactation. Nat Commun, 12(1):5801(2021) [pubmed]

submitter keyword: C. elegans, yolk, ageing, semelparity, reproductive death, milk

Graham W Taylor
contact affiliation	Wolfson Drug Discovery Unit Centre for Amyloidosis & Acute Phase Proteins Division of Medicine, Royal Free Campus University College London Rowland Hill Street, London NW3 2PF, UK
contact email	graham.taylor@ucl.ac.uk
lab head
Graham Taylor
contact affiliation	University College London
contact email	graham.taylor@ucl.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025472
     1. Label: PRIDE project
     2. Name: C. elegans provide "milk" for their young