PXD025457

PXD025457 is an original dataset announced via ProteomeXchange.

Title	Quantitative tyrosine phosphoproteome profiling of GAS6-AXL signaling network
Description	Overexpression and amplification of AXL receptor tyrosine kinase (RTK) has been found in several hematologic and solid malignancies. Activation of AXL by its ligand GAS6 can enhance tumor-promoting processes such as proliferation, migration, invasion, and survival. Despite the important role of AXL in cancer development, a deep and quantitative mapping of its signaling transduction has not been performed. Here, we used a mass spectrometry-based quantitative proteomic approach to characterize the temporal dynamics of the phosphotyrosine proteome of MDA-MB-231 cells stimulated with GAS6
HostingRepository	PRIDE
AnnounceDate	2021-08-24
AnnouncementXML	Submission_2021-08-24_02:03:03.160.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-19 00:13:37	ID requested
⏵ 1	2021-08-24 02:03:03	announced

Dataset with its publication pending

submitter keyword: AXL , breast cancer, TMT, phosphorylation, mas spectrometry

Akhilesh Pandey
contact affiliation	Mayo Clinic
contact email	pandey.akhilesh@mayo.edu
lab head
Akhilesh Pandey
contact affiliation	Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD025457

PRIDE project URI

• PRIDE
  1. PXD025457
     1. Label: PRIDE project
     2. Name: Quantitative tyrosine phosphoproteome profiling of GAS6-AXL signaling network