PXD025440

PXD025440 is an original dataset announced via ProteomeXchange.

Title	Exploration of peptides that are increased in the plasma of diabetic mice and are the substrate of dipeptidyl peptidase III
Description	Diabetes mellitus (DM) causes the change in the components of the plasma, which may induce tissue and organ injuries, including the heart and kidney. In the diabetic model db/db mice, intravenous injection of purified dipeptidyl peptidase III (DPPIII) attenuated the heart and kidney damages provoked by DM without alteration in blood glucose level. This led us to hypothesize that there might be peptide(s) that are involved in the progression of the DM-mediated damages and are cleaved by DPPIII. To explore the peptides, the whole peptidomics analysis was conducted using tandem mass spectrometry, in which peptides derived from the plasma of PBS-infused C57BL/6 mice, PBS-infused db/db mice, and DPPIII-treated db/db mice were compared. All of the lists of the peptides in the three mouse groups were shown in the raw data formatted and excel files.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_00:37:59.512.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akio Shimizu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-16 06:19:58	ID requested
⏵ 1	2022-02-17 00:38:00	announced

Komeno M, Pang X, Shimizu A, Molla MR, Yasuda-Yamahara M, Kume S, Rahman NIA, Soh JEC, Nguyen LKC, Ahmat Amin MKB, Kokami N, Sato A, Asano Y, Maegawa H, Ogita H, Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice. J Biol Chem, 296():100761(2021) [pubmed]

submitter keyword: mouse, plasma, peptide, peptidase, diabetes mellitus

Hisakazu Ogita
contact affiliation	Shiga University of Medical Science
contact email	hogita@belle.shiga-med.ac.jp
lab head
Akio Shimizu
contact affiliation	Shiga University of Medical Science
contact email	shimizua@belle.shiga-med.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD025440

PRIDE project URI

• PRIDE
  1. PXD025440
     1. Label: PRIDE project
     2. Name: Exploration of peptides that are increased in the plasma of diabetic mice and are the substrate of dipeptidyl peptidase III