PXD025396

PXD025396 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Regulation of the stress proteome by SCD1
Description	Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation prevents cytotoxic stress but the mechanisms are diffuse. We investigated changes in the proteome of NIH-3T3 fibroblasts upon induction of cytotoxic stress (valinomycin or myrtucommulone A) and SCD1 inhibition (CAY10566) and addressed the potential of PI(18:1/18:1) and PI(16:0/16:0) to compensate for the decrease in SCD1 activity.
HostingRepository	PRIDE
AnnounceDate	2022-04-06
AnnouncementXML	Submission_2022-05-31_01:42:33.569.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Konstantin Neukirch
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-14 06:10:56	ID requested
1	2022-04-06 03:27:11	announced
⏵ 2	2022-05-31 01:42:34	announced	2022-05-31: Updated publication reference for PubMed record(s): 35624087.

Publication List

Th, ü, rmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, L, ö, ser K, Grander J, Hotze M, Harder S, D, ö, ding A, Me, ß, ner M, Troisi F, Ardelt M, Schl, ü, ter H, Pachmayr J, Guti, é, rrez-Guti, é, rrez Ó, Rudolph KL, Thedieck K, Schulze-Sp, ä, te U, Gonz, á, lez-Est, é, vez C, Kosan C, Svato, š A, Kwiatkowski M, Koeberle A, PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling. Nat Commun, 13(1):2982(2022) [pubmed]

Th, ü, rmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, L, ö, ser K, Grander J, Hotze M, Harder S, D, ö, ding A, Me, ß, ner M, Troisi F, Ardelt M, Schl, ü, ter H, Pachmayr J, Guti, é, rrez-Guti, é, rrez Ó, Rudolph KL, Thedieck K, Schulze-Sp, ä, te U, Gonz, á, lez-Est, é, vez C, Kosan C, Svato, š A, Kwiatkowski M, Koeberle A, PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling. Nat Commun, 13(1):2982(2022) [pubmed]

Keyword List

submitter keyword: Mouse fibroblast, stress signaling, UPR, ERAD, autophagy, programmed cell death, monounsaturated fatty acid, phospholipid

submitter keyword: Mouse fibroblast, stress signaling, UPR, ERAD, autophagy, programmed cell death, monounsaturated fatty acid, phospholipid

Contact List

Andreas Koeberle
contact affiliation	Michael Popp Institute, University of Innsbruck, Austria
contact email	andreas.koeberle@uibk.ac.at
lab head
Konstantin Neukirch
contact affiliation	Michael Popp Institute, University of Innsbruck
contact email	konstantin.neukirch@uibk.ac.at
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD025396
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD025396

PRIDE project URI

Repository Record List

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