PXD025360 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Membrane substrates of HtrA from Helicobacter pylori |
Description | High temperature requirement A (HtrA) is a serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial cells was identified as the first HtrA substrate. HtrA-mediated hCdh1 cleavage and subsequent disruption of intercellular adhesion are considered as important steps in H. pylori pathogenesis. In this study, we performed a proteomic profiling of H. pylori HtrA (HpHtrA) to decipher the complex mechanism how H. pylori can interfere with epithelial barrier integrity. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-17 |
AnnouncementXML | Submission_2022-02-17_00:34:45.217.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marko Fonovic |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-13 01:54:16 | ID requested | |
⏵ 1 | 2022-02-17 00:34:46 | announced | |
Publication List
Bernegger S, Vidmar R, Fonovic M, Posselt G, Turk B, Wessler S, Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells. Cell Commun Signal, 19(1):108(2021) [pubmed] |
Keyword List
submitter keyword: Desmoglein, membrane, substrate, Helicobacter pylori, HtrA, protease |
Contact List
Marko Fonovic |
contact affiliation | Department of Biochemicstry and Molecular and Structural Biology Jozef Stefan Institute Jamova cesta 39 1000 Ljubljana, Slovenia |
contact email | marko.fonovic@ijs.si |
lab head | |
Marko Fonovic |
contact affiliation | Jozef Stefan Institute |
contact email | marko.fonovic@ijs.si |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD025360 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025360
- Label: PRIDE project
- Name: Membrane substrates of HtrA from Helicobacter pylori