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PXD025360

PXD025360 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMembrane substrates of HtrA from Helicobacter pylori
DescriptionHigh temperature requirement A (HtrA) is a serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial cells was identified as the first HtrA substrate. HtrA-mediated hCdh1 cleavage and subsequent disruption of intercellular adhesion are considered as important steps in H. pylori pathogenesis. In this study, we performed a proteomic profiling of H. pylori HtrA (HpHtrA) to decipher the complex mechanism how H. pylori can interfere with epithelial barrier integrity.
HostingRepositoryPRIDE
AnnounceDate2022-02-17
AnnouncementXMLSubmission_2022-02-17_00:34:45.217.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarko Fonovic
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-13 01:54:16ID requested
12022-02-17 00:34:46announced
Publication List
Bernegger S, Vidmar R, Fonovic M, Posselt G, Turk B, Wessler S, Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells. Cell Commun Signal, 19(1):108(2021) [pubmed]
Keyword List
submitter keyword: Desmoglein, membrane, substrate, Helicobacter pylori, HtrA, protease
Contact List
Marko Fonovic
contact affiliationDepartment of Biochemicstry and Molecular and Structural Biology Jozef Stefan Institute Jamova cesta 39 1000 Ljubljana, Slovenia
contact emailmarko.fonovic@ijs.si
lab head
Marko Fonovic
contact affiliationJozef Stefan Institute
contact emailmarko.fonovic@ijs.si
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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