PXD025360

PXD025360 is an original dataset announced via ProteomeXchange.

Title	Membrane substrates of HtrA from Helicobacter pylori
Description	High temperature requirement A (HtrA) is a serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial cells was identified as the first HtrA substrate. HtrA-mediated hCdh1 cleavage and subsequent disruption of intercellular adhesion are considered as important steps in H. pylori pathogenesis. In this study, we performed a proteomic profiling of H. pylori HtrA (HpHtrA) to decipher the complex mechanism how H. pylori can interfere with epithelial barrier integrity.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_00:34:45.217.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marko Fonovic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-13 01:54:16	ID requested
⏵ 1	2022-02-17 00:34:46	announced

Bernegger S, Vidmar R, Fonovic M, Posselt G, Turk B, Wessler S, Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells. Cell Commun Signal, 19(1):108(2021) [pubmed]

submitter keyword: Desmoglein, membrane, substrate, Helicobacter pylori, HtrA, protease

Marko Fonovic
contact affiliation	Department of Biochemicstry and Molecular and Structural Biology Jozef Stefan Institute Jamova cesta 39 1000 Ljubljana, Slovenia
contact email	marko.fonovic@ijs.si
lab head
Marko Fonovic
contact affiliation	Jozef Stefan Institute
contact email	marko.fonovic@ijs.si
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD025360

PRIDE project URI

• PRIDE
  1. PXD025360
     1. Label: PRIDE project
     2. Name: Membrane substrates of HtrA from Helicobacter pylori