PXD025224

PXD025224 is an original dataset announced via ProteomeXchange.

Title	Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis
Description	Background: Schistosoma japonicum (S. japonicum) is a parasitic flatworm that is the aetiological agent of human schistosomiasis, an important cause of hepatic fibrosis. Schistosomiasis-induced hepatic fibrosis is a consequence of the highly fibrogenic nature of egg-induced granulomatuous lesions, the main pathogenic factor of schistosomiasis. Although global awareness of the association between schistosomiasis-indued hepatic fibrosis and s. japonicum infection is increasing, little is known about the molecular differences associated with rapid progression to schistosomiasis in cirrhotic patients. Methods: We systematically used data-independent acquisition (DIA)-based liquid chromatography-mass spectrometry to identify differentially expressed proteins in serum samples from patients with advanced S. japonicum-induced hepatic fibrosis. Results: On the basis of our analysis, we identified 1,144 proteins, among which 66 were differentially expressed between the healthy control and SHF-F2 groups and 214 were differentially expressed between the SHF-F2 and SHF-F4 groups (up- or downregulation of at least 1.5-fold in serum samples). Furthermore, our results indicated that two selected proteins (C1QA and CFD) are potential biomarkers for distinguishing patients with SHF-F2 and SHF-F4 resulting from S. japonicum infection. Conclusions: This report is the first to provide a global proteomic profile of serum samples from patients with advanced S. japonicum-induced hepatic fibrosis. C1QA and CFD are potentially diagnostic markers for patients with SHF-F2 and SHF-F4 resulting from S. japonicum infection, although further large-scale studies are needed. Our DIA-based quantitative proteomic analysis revealed molecular differences among individuals with different stages of advanced S. japonicum-induced hepatic fibrosis and might provide fundamental information for further detailed investigations.
HostingRepository	PRIDE
AnnounceDate	2022-09-06
AnnouncementXML	Submission_2022-09-06_13:54:15.169.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dahai Wei
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dihydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-06 07:38:59	ID requested
⏵ 1	2022-09-06 13:54:15	announced

Huang J, Yin X, Zhang L, Yao M, Wei D, Wu Y, Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis. Parasit Vectors, 14(1):232(2021) [pubmed]

submitter keyword: Quantitative proteomics, Schistosomiasis-induced hepatic fibrosis

Dahai Wei
contact affiliation	The Affiliated Hospital of Jiaxing University
contact email	wei_dahai@hotmail.comn
lab head
Dahai Wei
contact affiliation	The Affiliated Hospital of Jiaxing University
contact email	wei_dahai@hotmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025224
     1. Label: PRIDE project
     2. Name: Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis