PXD025187

PXD025187 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of bystander effects induced by irradiated chondrosarcoma cells
Description	To understand the cellular response of bystander cells, we performed a 2D gel-based proteomic study of the chondrocyte receiving the conditioned medium of low dose irradiated chondrosarcoma cells. The proteomic analysis of the bystander chondrocytes highlighted 20 proteins spots that were significantly modified at low dose, implicating several cellular mechanisms, such as oxidative stress responses, cellular motility and exosomes pathways. Several of these candidates and cellular mechanisms were confirmed by functional analysis, such as 8-oxodG quantification, western blot and wound-healing migration tests.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_00:21:05.493.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	sonia hem
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-06 03:59:33	ID requested
⏵ 1	2022-02-17 00:21:06	announced

Tudor M, Gilbert A, Lepleux C, Temelie M, Hem S, Armengaud J, Brotin E, Haghdoost S, Savu D, Chevalier F, A Proteomic Study Suggests Stress Granules as New Potential Actors in Radiation-Induced Bystander Effects. Int J Mol Sci, 22(15):(2021) [pubmed]

submitter keyword: chondrosarcoma, bystander signalling, proteomic analysis, secretome

Chevalier Francois
contact affiliation	UMR6252 CIMAP, team « Applications in Radiobiology with Accelerated Ions”, CEA - CNRS - ENSICAEN - Université de Caen Normandie, Caen, France.
contact email	chevalier@ganil.fr
lab head
sonia hem
contact affiliation	INRA
contact email	sonia.hem@supagro.inra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD025187

PRIDE project URI

• PRIDE
  1. PXD025187
     1. Label: PRIDE project
     2. Name: Proteomic analysis of bystander effects induced by irradiated chondrosarcoma cells