PXD025185

PXD025185 is an original dataset announced via ProteomeXchange.

Title	Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation
Description	In this study we aimed to provide a detailed comparative description of the fragmentation sites of amyloid LCs in multiple organs of an individual patient.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-11_23:50:54.704.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giulia Mazzini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue; monohydroxylated residue; dimethylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-06 03:18:46	ID requested
⏵ 1	2022-08-11 23:50:55	announced

Mazzini G, Ricagno S, Caminito S, Rognoni P, Milani P, Nuvolone M, Basset M, Foli A, Russo R, Merlini G, Palladini G, Lavatelli F, Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation. FEBS J, 289(2):494-506(2022) [pubmed]

submitter keyword: Amyloid fibrils, Immunoglobulin Light chains, Proteolysis, Proteomics, Amyloidogenesis

Giovanni Palladini
contact affiliation	Amyloidosis Treatment and Research Center, Fondazione IRCCS Policlinico San Matteo
contact email	g.palladini@smatteo.pv.it
lab head
Giulia Mazzini
contact affiliation	Fondazione IRCCS Policlinico San Matteo
contact email	g.mazzini@smatteo.pv.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD025185

PRIDE project URI

• PRIDE
  1. PXD025185
     1. Label: PRIDE project
     2. Name: Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation