PXD025155

PXD025155 is an original dataset announced via ProteomeXchange.

Title	Marine bacterial polysaccharide EPS11 inhibits metastasis and invasion of liver cancer cells by directly targeting type I collagen
Description	Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for approximately 90%, and it has a five-year survival rate around only 30–40%. Similar to other kinds of cancers, tumor metastasis remains the primary cause of mortality of HCC patients. It is well known that metastasis is a multistage process that requires cancer cell detachment from the primary tumor, survival in the circulation, settlement at distant sites and growth. During this process, metastatic cells go through detachment, migration, invasion and adhesion, and inhibition of any one of these steps has the potential to block the entire metastatic process. However, there is very little advancement in the area of blocking tumor metastasis, therefore, new effective agents possessing anti-metastasis activities are urgently needed for better prevention and treatment of HCC and other cancers. Our previous results suggested that EPS11, a novel marine bacterial polysaccharide, might be a potential drug candidate for human non-small cell lung carcinoma treatment. In this study, we further investigate the anticancer mechanisms against liver cancer and the anti-metastatic effects of EPS11.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_00:14:06.643.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ge Liu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-01 08:27:57	ID requested
⏵ 1	2022-02-17 00:14:07	announced

Liu G, Liu R, Shan Y, Sun C, Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I. J Biol Chem, 297(4):101133(2021) [pubmed]

submitter keyword: polysaccharide

liver cancer

collagen;

Ge Liu
contact affiliation	Institute of Oceanology, Chinese Academy of Sciences
contact email	liug878@163.com
lab head
Ge Liu
contact affiliation	Institute of Oceanology, Chinese Academy of Sciences
contact email	liuge@qdio.ac.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025155
     1. Label: PRIDE project
     2. Name: Marine bacterial polysaccharide EPS11 inhibits metastasis and invasion of liver cancer cells by directly targeting type I collagen