PXD025114

PXD025114 is an original dataset announced via ProteomeXchange.

Title	Targeting IFN-γ-inducible lysosomal thiol reductase Overcomes Chemoresistance in AML through Regulating the ROS-mediated mitochondrial damage
Description	Our work demonstrated that the inhibition of GILT increases AML chemo-sensitivity through elevating ROS level and induce oxidative mitochondrial damage-mediated apoptosis, and inhibition of the PI3K/Akt/NRF2 pathway enhances the intracellular oxidative state by disrupting redox homeostasis. Our study provides a potentially effective way to overcome chemoresistance of AML.
HostingRepository	iProX
AnnounceDate	2021-03-31
AnnouncementXML	Submission_2023-02-19_23:33:39.872.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuaixin Gao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-30 23:14:22	ID requested
1	2021-04-14 19:34:55	announced
⏵ 2	2023-02-19 23:33:40	announced	2023-02-20: Update publication information.

Niu LT, Wang YQ, Wong CCL, Gao SX, Mo XD, Huang XJ, -inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage. Transl Oncol, 14(9):101159(2021) [pubmed]

submitter keyword: AML, chemoresistance, LSC, GILT, ROS, mitochondrial damage, NRF2

Xiao-Jun Huang
contact affiliation	Peking University First Hospital
contact email	huangxiaojun@bjmu.edu.cn
lab head
Shuaixin Gao
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	gaoshuaixin@126.com
dataset submitter

iProX dataset URI