PXD025048

PXD025048 is an original dataset announced via ProteomeXchange.

Title	Analysis of Pancreatic Extracellular Matrix Protein Post-Translational Modifications via Electrostatic Repulsion-Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry
Description	The pancreas is a vital organ with digestive and endocrine roles, and diseases of the pancreas affect millions of people yearly. A better understanding of the pancreas proteome and its dynamic post-translational modifications (PTMs) is necessary to engineer higher fidelity tissue analogues for use in transplantation. The extracellular matrix (ECM) has major roles in binding and signaling essential to the viability of insulin-producing islets of Langerhans. To analyze post-translational modifications (PTMs) in the pancreas, native and decellularized tissues from four donors were analyzed.
HostingRepository	PRIDE
AnnounceDate	2021-08-06
AnnouncementXML	Submission_2021-08-06_03:52:04.237.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dylan Nicholas Tabang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; complex glycosylation; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-29 02:44:17	ID requested
⏵ 1	2021-08-06 03:52:04	announced

Tabang DN, Cui Y, Tremmel DM, Ford M, Li Z, Sackett SD, Odorico JS, Li L, electrostatic repulsion-hydrophilic interaction chromatography coupled with mass spectrometry. Mol Omics, 17(5):652-664(2021) [pubmed]

submitter keyword: electrostatic repulsion-hydrophilic interaction chromatography (ERLIC), post-translational modifications (PTM), phosphopeptide, glycopeptide, mass spectrometry, pancreas, extracellular matrix

Lingjun Li
contact affiliation	School of Pharmacy, University of Wisconsin-Madison
contact email	lingjun.li@wisc.edu
lab head
Dylan Nicholas Tabang
contact affiliation	University of Wisconsin-Madison
contact email	tabang@wisc.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025048
     1. Label: PRIDE project
     2. Name: Analysis of Pancreatic Extracellular Matrix Protein Post-Translational Modifications via Electrostatic Repulsion-Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry