PXD025022 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic characterization of the cellular effects of AHR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages |
Description | Sensing of microbial tryptophan catabolites by the aryl hydrocarbon receptor (AhR) plays a pivotal role in host-microbiome homeostasis by modulating the host immune response. Thereby the involved cellular processes triggered by the metabolites are largely unknown. We analyzed proteomic changes in macrophages trough 24h after treatment with the tryptophan metabolites indole-3-acetic acid (I3AA) or indole-3-aldehyde (IAld), as well as the prototypic AhR-ligand Benzo(a)pyrene (BaP) in the absence and presence of LPS to identify affected processes and pathways. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-03 |
AnnouncementXML | Submission_2021-11-03_07:19:12.552.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD025022 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Henning Großkopf |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-26 00:11:30 | ID requested | |
⏵ 1 | 2021-11-03 07:19:14 | announced | |
Publication List
Walter K, Grosskopf H, Karkossa I, von Bergen M, Schubert K, Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages. Int J Environ Res Public Health, 18(19):(2021) [pubmed] |
Keyword List
submitter keyword: AhR, human macrophages, Tryptophan catabolites, Benzo[a]pyrene, Indole-3-aldehyde, Indole-3-acetic acide, Lipopolysaccharides, metabolism, proteomics, LC-MS/MS, TMT |
Contact List
Martin von Bergen |
contact affiliation | Department of Molecular Systems Biology; Helmholtz Center for Environmental Research - UFZ, Leipzig, Germany |
contact email | martin.vonbergen@ufz.de |
lab head | |
Henning Großkopf |
contact affiliation | Molecular Systems Biology Helmholtz Centre for Environmental Research GmbH - UFZ Leipzig, Germany |
contact email | henning.grosskopf@ufz.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025022
- Label: PRIDE project
- Name: Proteomic characterization of the cellular effects of AHR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages