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PXD025022

PXD025022 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic characterization of the cellular effects of AHR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages
DescriptionSensing of microbial tryptophan catabolites by the aryl hydrocarbon receptor (AhR) plays a pivotal role in host-microbiome homeostasis by modulating the host immune response. Thereby the involved cellular processes triggered by the metabolites are largely unknown. We analyzed proteomic changes in macrophages trough 24h after treatment with the tryptophan metabolites indole-3-acetic acid (I3AA) or indole-3-aldehyde (IAld), as well as the prototypic AhR-ligand Benzo(a)pyrene (BaP) in the absence and presence of LPS to identify affected processes and pathways.
HostingRepositoryPRIDE
AnnounceDate2021-11-03
AnnouncementXMLSubmission_2021-11-03_07:19:12.552.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD025022
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHenning Großkopf
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-26 00:11:30ID requested
12021-11-03 07:19:14announced
Publication List
Walter K, Grosskopf H, Karkossa I, von Bergen M, Schubert K, Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages. Int J Environ Res Public Health, 18(19):(2021) [pubmed]
Keyword List
submitter keyword: AhR, human macrophages, Tryptophan catabolites, Benzo[a]pyrene, Indole-3-aldehyde, Indole-3-acetic acide, Lipopolysaccharides, metabolism, proteomics, LC-MS/MS, TMT
Contact List
Martin von Bergen
contact affiliationDepartment of Molecular Systems Biology; Helmholtz Center for Environmental Research - UFZ, Leipzig, Germany
contact emailmartin.vonbergen@ufz.de
lab head
Henning Großkopf
contact affiliationMolecular Systems Biology Helmholtz Centre for Environmental Research GmbH - UFZ Leipzig, Germany
contact emailhenning.grosskopf@ufz.de
dataset submitter
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Dataset FTP location
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