PXD024998

PXD024998 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Analysis of the sarkosyl-insoluble proteomes of Parkinson’s disease and Multiple System Atrophy subject brain samples
Description	Aggregated alpha-synuclein (α-syn) is a principal constituent of Lewy bodies (LBs) and glial cytoplasmic inclusions (GCIs) that are observed respectively inside neurons in Parkinson’s disease (PD) and oligodendrocytes in multiple system atrophy (MSA). Yet, the cellular origin, the exact pathophysiological role, and the mechanism of formation of these inclusions remain to be elucidated. It has recently been proposed that pathological α-syn inclusions are capable of eventually causing the demise of the host cell by virtue of the cumulative sequestration of partner proteins and organelles. In particular, the hypothesis of a local cross-seeding of other fibrillization-prone proteins like tau or TDP-43 has also been put forward. The objective of this study was to examine the composition of these inclusions to gain insight into their origin and mechanisms of formation. We submitted sarkosyl-insoluble extracts of post-mortem brain tissue from PD and MSA patients and control subjects to a comparative proteomic analysis to address these points.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-16_23:57:46.314.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephane Claverol
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-25 03:42:05	ID requested
⏵ 1	2022-02-16 23:57:47	announced

Publication List

Laferri, è, re F, Claverol S, Bezard E, De Giorgi F, Ichas F, -synuclein aggregates from MSA and Parkinson's disease. NPJ Parkinsons Dis, 8(1):10(2022) [pubmed]

Laferri, è, re F, Claverol S, Bezard E, De Giorgi F, Ichas F, -synuclein aggregates from MSA and Parkinson's disease. NPJ Parkinsons Dis, 8(1):10(2022) [pubmed]

Keyword List

submitter keyword: alpha-synuclein
protein aggregates
Parkinson’s disease
Multiple System Atrophy
insoluble proteome

submitter keyword: alpha-synuclein

protein aggregates

Parkinson’s disease

Multiple System Atrophy

insoluble proteome

Contact List

Marc Bonneu
contact affiliation	Plateforme proteome, Univ. Bordeaux, Bordeaux, France
contact email	marc.bonneu@gmail.com
lab head
Stephane Claverol
contact affiliation	Plateforme Proteome
contact email	stephane.claverol@u-bordeaux.fr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD024998
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD024998

PRIDE project URI

Repository Record List

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