PXD024961

PXD024961 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Deficiency in Sirtuin3 rewires mitochondrial metabolism and increases maximum lifespan under caloric restriction - Mitochondrial Acetylation Stoichiometry
Description	Quantification of acetylation stoichiometry from mitochondrial enriched proteins from mouse livers. Conditions compared include genotype, diet, and age; i.e. Sirt3 KO vs Sirt3 WT, caloric restricted (CR) diet vs control diet (CD), and 5 months old vs 25 months old.
HostingRepository	MassIVE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_15:15:59.070.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexis Lawton
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Acetyl; Acetyl:2H(3); Oxidation; Carbamidomethyl
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-23 09:01:30	ID requested
⏵ 1	2024-01-26 15:15:59	announced

Publication List

Dhillon RS, Qin YA, van Ginkel PR, Fu VX, Vann JM, Lawton AJ, Green CL, Manchado-Gobatto FB, Gobatto CA, Lamming DW, Prolla TA, Denu JM, SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction. Aging Cell, 21(12):e13721(2022) [pubmed]

Dhillon RS, Qin YA, van Ginkel PR, Fu VX, Vann JM, Lawton AJ, Green CL, Manchado-Gobatto FB, Gobatto CA, Lamming DW, Prolla TA, Denu JM, SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction. Aging Cell, 21(12):e13721(2022) [pubmed]

Keyword List

submitter keyword: Acetylation, Stoichiometry, Mitochondria, Metabolism, Sirtuins, Sirt3, Aging, Caloric Restriction

submitter keyword: Acetylation, Stoichiometry, Mitochondria, Metabolism, Sirtuins, Sirt3, Aging, Caloric Restriction

Contact List

John Denu
contact affiliation	University of Wisconsin - Madison
contact email	john.denu@wisc.edu
lab head
Alexis Lawton
contact affiliation	University of Wisconsin - Madison
contact email	alawton2@wisc.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000087085/