PXD024919

PXD024919 is an original dataset announced via ProteomeXchange.

Title	Allobaculum mucolyticum is a novel mucin degrader
Description	The human gut microbiota plays a central role in intestinal health and disease. However, many of its bacterial constituents are functionally still largely unexplored. A crucial prerequisite for bacterial survival and proliferation is the creation and/or exploitation of an own niche. For many bacterial species that are linked to human disease, the inner mucus layer was found to be an important niche. Allobaculum mucolyticum, is a novel, IBD-associated species that is thought be closely associated with the host epithelium. To explore how this bacterium is able to effectively colonize this niche, we screened its genome for factors that may contribute to mucosal colonization. We identified multiple secreted Carbohydrate Active Enzymes (CAZymes). These CAZymes are able to degrade mucin O-glycans after which some of the liberated monosaccharides can be utilized for bacterial growth. The enzymatic degradation of the mucin glycans may sensitize the mucus layer for further degradation and bacterial entry. Therefore, these enzymes may play a key role in bacterial colonization of the inner mucus layer, and thus may pose an interesting target for future therapeutic intervention.
HostingRepository	PRIDE
AnnounceDate	2021-09-22
AnnouncementXML	Submission_2021-09-22_03:27:00.610.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guido van Mierlo
SpeciesList	scientific name: Allobaculum sp.; NCBI TaxID: 1872463;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-22 04:37:26	ID requested
⏵ 1	2021-09-22 03:27:01	announced

van Muijlwijk GH, van Mierlo G, Jansen PWTC, Vermeulen M, Bleumink-Pluym NMC, Palm NW, van Putten JPM, de Zoete MR, Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader. Gut Microbes, 13(1):1966278(2021) [pubmed]

submitter keyword: Allobaculum mucolyticum, IBD, secretome

Michiel Vermeulen
contact affiliation	Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
contact email	michiel.vermeulen@science.ru.nl
lab head
Guido van Mierlo
contact affiliation	Radboud University
contact email	guidovanmierlo@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD024919

PRIDE project URI

• PRIDE
  1. PXD024919
     1. Label: PRIDE project
     2. Name: Allobaculum mucolyticum is a novel mucin degrader