PXD024916

PXD024916 is an original dataset announced via ProteomeXchange.

Title	One-day thermal regime extends lifespan
Description	Environmental factors such as temperature can modulate animal’s lifespan. However, the underlying mechanisms remain largely undefined. Through proteomic analysis of C. elegans at different time points (young adult, middle age, and old age) and under two temperature conditions (20°C and 25°C), we found that temperature affects C. elegans lifespan largely by modulating the proteostasis. Surprisingly, although animals live shorter at the higher temperature, we found that worms cultured at 25°C for one day at early adulthood promotes the protein homeostasis by decreasing the synthesis and increasing the degradation, suggesting the beneficial effects. Consistent with the finding, animals shifting from 20°C to 25°C for 24 hours between the larval L4 to adult Day 3 stages indeed live longer and are more resistant to stresses. Furthermore, we found that the one-day thermal induced lifespan extension is mediated by the FOXO transcriptional factor DAF-16. These results reveal an unexpected and complicated mechanism underlying the temperature effects on aging, which could potentially aid to develop strategies for treating aging related diseases.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:36:07.432.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jichang Huang
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-22 04:37:07	ID requested
1	2023-03-10 19:52:50	announced
⏵ 2	2023-11-14 08:36:08	announced	2023-11-14: Updated project metadata.

Huang J, Wang K, Wang M, Wu Z, Xie G, Peng Y, Zhang Y, Zhang X, Shao Z, One-day thermal regime extends the lifespan in Caenorhabditis elegans. Comput Struct Biotechnol J, 21():495-505(2023) [pubmed]

submitter keyword: C. elegans,proteomics,lifespan,temperature

Xumin Zhang
contact affiliation	State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, P. R. China
contact email	xumin_zhang@fudan.edu.cn
lab head
Jichang Huang
contact affiliation	School of Life Sciences, Fudan University
contact email	14110700074@fudan.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD024916

PRIDE project URI

• PRIDE
  1. PXD024916
     1. Label: PRIDE project
     2. Name: One-day thermal regime extends lifespan