PXD024914

PXD024914 is an original dataset announced via ProteomeXchange.

Title	Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer’s Disease
Description	The linear sequence of amino acids in a protein folds into a 3D structure to execute protein activity and function, but it is still challenging to profile the 3D structure at the proteome scale. Here, we present a method of native protein tandem mass tag (TMT) profiling of Lys accessibility and its application to investigate structural alterations in human brain specimens of Alzheimer’s disease (AD).
HostingRepository	PRIDE
AnnounceDate	2021-03-23
AnnouncementXML	Submission_2021-03-22_23:15:08.065.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kaiwen Yu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-22 04:37:03	ID requested
⏵ 1	2021-03-22 23:15:09	announced

Yu K, Niu M, Wang H, Li Y, Wu Z, Zhang B, Haroutunian V, Peng J, Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer's Disease. J Am Soc Mass Spectrom, 32(4):936-945(2021) [pubmed]

submitter keyword: proteomics, structural mass spectrometry, tandem mass tag, structuromics, Alzheimer’s disease, and tau

Junmin Peng
contact affiliation	Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
contact email	junmin.peng@stjude.org
lab head
Kaiwen Yu
contact affiliation	St Jude Children's Hospital
contact email	kaiwen.yu@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD024914

PRIDE project URI

• PRIDE
  1. PXD024914
     1. Label: PRIDE project
     2. Name: Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer’s Disease