PXD024910

PXD024910 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics analysis reveals novel insights into mechanisms of action of Disulfiram (DSF)
Description	The new uses of the old drugs may reduce cost and shortens the production cycle of research and development, especially that approved by FDA for important clinical conditions. Alcohol abuse Disulfiram (DSF) has been proven safe and shows the promising anti-tumor effect in may preclinical studies. However, the potential side effects of DSF on tumor remain unknown. In this study, we explored the role of DSF in cancer cells and searched for the differential expressed protein after DSF treatment in the HeLa cells. To fully understand the mechanism of action of DSF with a systems perspective, we employed a quantitative proteomics strategy to systematically identify potential targets of DSF. In total, 201 proteins were dys-regulated significantly after DSF exposure, implying that they may be potential targets of DSF. Analysis of this data on a system level revealed major changes of proteins involved in diverse biological processes, including metabolic process and response to stimulus.
HostingRepository	PRIDE
AnnounceDate	2021-11-27
AnnouncementXML	Submission_2021-11-27_00:18:42.358.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	peng zheng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-22 04:36:34	ID requested
⏵ 1	2021-11-27 00:18:43	announced

Zheng P, Liu C, Wu Y, Xu R, Chen Y, Hu F, Chen Z, Zhang T, Quantitative proteomics analysis reveals novel insights into mechanisms of action of disulfiram (DSF). Proteomics Clin Appl, 16(1):e2100031(2022) [pubmed]

submitter keyword: DSF

quantitative proteomics

migration

invasion;

peng zheng
contact affiliation	Institute of Biology and Medicine, College of Life Science and Healthy, Wuhan University of Science and Technology, Wuhan, China,
contact email	pengzh1984@wust.edu.cn
lab head
peng zheng
contact affiliation	Wuhan university of science and technology
contact email	pengzh1984@wust.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024910
     1. Label: PRIDE project
     2. Name: Quantitative proteomics analysis reveals novel insights into mechanisms of action of Disulfiram (DSF)