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PXD024906 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSpatial discordances between mRNAs and proteins in the intestinal epithelium
DescriptionWe obtained a spatial measurement of RNA and Proteins in the small intestinal epithelium along the crypt-villus axis. We found that both were spatially heterogeneous, yet often spatially anti-correlated. We developed a Bayesian approach to infer protein translation and degradation rates from the combined spatial profiles, and demonstrate that space-independent protein-synthesis delays can explain the mRNA-protein discordances. Our work provides a proteomic spatial blueprint of the Intestinal epithelium and highlights the importance of protein measurements for inferring states of tissue cells that operate outside of steady state
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlon Savidor
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue; deamidated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-22 04:36:14ID requested
12021-11-02 04:34:56announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: small intestine
crypt-villus axis
spatial heterogeneity
RNA-protein dynamics
Bayesian modeling, proteomics
Contact List
Prof. Shalev Itzkovitz
contact affiliationDepartment of Molecular Cell Biology Faculty of Biology Weizmann Institute of Science Rehovot, Israel
contact emailshalev.itzkovitz@weizmann.ac.il
lab head
Alon Savidor
contact affiliationThe Weizmann Institute of Science
contact emailalon.savidor@weizmann.ac.il
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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