PXD024904

PXD024904 is an original dataset announced via ProteomeXchange.

Title	Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis
Description	Meningitis is a life-threatening condition characterized by the inflammation of the leptomeningeal membranes surrounding the brain and spinal cord. The term meningitis is an umbrella term and includes several different etiologies. Acute bacterial meningitis (ABM) is one of the leading causes of death due to infectious diseases worldwide and is associated with rapid disease progression, high mortality rates and increased risk of long-term neurological sequelae in survivors. As meningitis is caused by numerous different pathogens, the host-response is typically highly variable and it is currently unknown if different pathogens can introduce specific proteome changes in the cerebrospinal fluid (CSF). By using LC-MS/MS we have generated assay libraries of 8 unique bacterial strains that commonly cause meningitis. These libraries can be used to mine CSF of meningitis samples to detect bacterial peptides.
HostingRepository	PRIDE
AnnounceDate	2021-04-12
AnnouncementXML	Submission_2021-04-12_08:03:08.108.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anahita Bakochi
SpeciesList	scientific name: Streptococcus pneumoniae R6; NCBI TaxID: 171101; scientific name: Enterococcus faecalis; NCBI TaxID: 1351; scientific name: Streptococcus agalactiae serogroup V; NCBI TaxID: 216466; scientific name: Listeria monocytogenes serotype 1/2a; NCBI TaxID: 1906951; scientific name: Escherichia coli O157; NCBI TaxID: 1045010; scientific name: Streptococcus pyogenes M1 GAS; NCBI TaxID: 160490; scientific name: Pseudomonas aeruginosa PAO1; NCBI TaxID: 208964; scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-22 04:36:00	ID requested
⏵ 1	2021-04-12 08:03:08	announced

Bakochi A, Mohanty T, Pyl PT, Gueto-Tettay CA, Malmstr, ö, m L, Linder A, Malmstr, ö, m J, Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis. Elife, 10():(2021) [pubmed]

submitter keyword: Bacteria, LC-MS/MS, assay library

Johan Malmström
contact affiliation	Department of Clinical Science (IKVL), Lund Division of Infection Medicine Lund University Sweden
contact email	johan.malmstrom@med.lu.se
lab head
Anahita Bakochi
contact affiliation	Lund University
contact email	anahita.bakochi@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD024904

PRIDE project URI

• PRIDE
  1. PXD024904
     1. Label: PRIDE project
     2. Name: Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis