PXD024899

PXD024899 is an original dataset announced via ProteomeXchange.

Title	Decipering the molecular mechanism of ACE2 regulating A549 cells
Description	In the current study, using a lentivirus-based expression system in lung cancer cells (A549), we show that ACE2 overexpression reduces the viability and migratory potential of cancer cells, highlighting the robust anti-tumorigenic effects of ACE2 function. Moreover, a quantitative proteome-level comparison between ACE2 overexpressed (OE) and empty vector-controlled (NC) cells reveals a large number (227) of differentially expressed proteins (DEPs) that may have contributed to this phenomenon. Functional enrichment of these DEPs has uncovered that most of them perform binding activities and enzymatic reactions associated with metabolic pathways and various post-transcriptional gene expression regulatory mechanisms. Besides, cellular component analysis reveals that the DEPs function across a range of compartments within a cell with a relatively heterogeneous distribution.
HostingRepository	iProX
AnnounceDate	2021-03-22
AnnouncementXML	Submission_2023-02-12_23:50:12.474.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Linxin Xie
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ABI WIFF format

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-22 01:06:09	ID requested
1	2021-03-22 01:06:40	announced
⏵ 2	2023-02-12 23:50:13	announced	2023-02-13: Update publication information.

Xiao K, Song L, Bai Y, Liu P, Liu Y, Xie F, Xie L, Decipering the Molecular Mechanism of ACE2 Regulating A549 Cells. Front Genet, 12():653725(2021) [pubmed]

submitter keyword: ACE2, A549 cells , proteome-level comparison

Linxin Xie
contact affiliation	Chinese People’s Liberation Army (PLA) General Hospital
contact email	linxin_xie@sina.com
lab head
Linxin Xie
contact affiliation	Chinese People’s Liberation Army (PLA) General Hospital
contact email	linxin_xie@sina.com
dataset submitter

iProX dataset URI