PXD024883

PXD024883 is an original dataset announced via ProteomeXchange.

Title	Deep time-course proteomics of SARS-CoV and SARS-CoV-2 infected human lung epithelial cells (Calu-3) reveals strong induction of interferon-stimulated gene (ISG) expression by SARS-CoV-2 in contrast to SARS-CoV
Description	In the present study, we used data-independent acquisition mass spectrometry (DIA-MS) to analyse the protein expression in Calu-3 cells infected with SARS-CoV and SARS-CoV-2 over the time-course of 24 hours. About 8400 proteins were identified, from which about 90% could be quantified across the experiment. This results in a deep and comprehensive proteome map, which reflects time-dependent protein expression changes during SARS-CoV and SARS-CoV-2 infections and provides deep insights into the virus-specific immunmodulation of human lung cells.
HostingRepository	PRIDE
AnnounceDate	2022-02-18
AnnouncementXML	Submission_2022-02-18_09:09:35.849.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marica Grossegesse
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049; scientific name: Severe acute respiratory syndrome-related coronavirus; NCBI TaxID: 694009;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-19 07:07:03	ID requested
⏵ 1	2022-02-18 09:09:36	announced

Dataset with its publication pending

submitter keyword: SARS-CoV-2, SARS-CoV, Human lung cells, Calu-3

Andreas Nitsche
contact affiliation	ZBS1, Highly Pathogenic Viruses, Robert Koch-Institute, Germany
contact email	NitscheA@rki.de
lab head
Marica Grossegesse
contact affiliation	Robert Koch Institute
contact email	GrossegesseM@rki.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD024883

PRIDE project URI

• PRIDE
  1. PXD024883
     1. Label: PRIDE project
     2. Name: Deep time-course proteomics of SARS-CoV and SARS-CoV-2 infected human lung epithelial cells (Calu-3) reveals strong induction of interferon-stimulated gene (ISG) expression by SARS-CoV-2 in contrast to SARS-CoV