PXD024777
PXD024777 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome landscape of mouse oocyte mitochondria |
| Description | Mitochondria are essential organelles that provide energy for mammalian cells, with multiple functions such as signal transduction, cellular differentiation, and regulation of apoptosis. Compared with the mitochondria in somatic cells, oocyte mitochondria have an additional layer of importance since they are required for germ cell maturation, dysfunctions of which can lead to severe inherited disorders. Thus, a systematic proteomic profile of oocyte mitochondria is urgently needed for basic and clinical research, but has been hindered by the rarity of oocyte samples and technical challenges associated with capturing mitochondrial proteins from live oocytes. Here, in this work, using proximity labeling proteomics, we established a mitochondria-specific ascorbate peroxidase (APEX2) reaction in live GV staged oocytes of mouse and and explore oocyte mitochondrial proteomics. |
| HostingRepository | iProX |
| AnnounceDate | 2021-03-16 |
| AnnouncementXML | Submission_2023-02-19_23:36:28.292.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Na Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | acetylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-03-16 21:04:41 | ID requested | |
| 1 | 2021-06-30 23:26:12 | announced | |
| ⏵ 2 | 2023-02-19 23:36:29 | announced | 2023-02-20: Update publication information. |
Publication List
| Zhang N, Sun AD, Sun SM, Yang R, Shi YY, Wang QL, Li XY, Ma JH, Yue W, Xie BT, Qiao J, Li M, Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile. Acta Pharmacol Sin, 42(12):2144-2154(2021) [pubmed] |
Keyword List
| submitter keyword: Oocyte, mitochondria |
Contact List
| Mo Li | |
|---|---|
| contact affiliation | Peking University Third Hospita |
| contact email | limo@hsc.pku.edu.cn |
| lab head | |
| Na Zhang | |
| contact affiliation | Peking University Third Hospital |
| contact email | zhangna9902@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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