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PXD024673

PXD024673 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAnalysis of mouse liver secretome and proteome during nonalcoholic steatohepatitis
DescriptionNon-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we interrogated hepatocyte protein secretion in two models of murine NASH to reveal striking hepatokine remodelling that is associated with insulin resistance and maladaptive lipid metabolism.
HostingRepositoryPRIDE
AnnounceDate2022-02-27
AnnouncementXMLSubmission_2022-02-27_14:34:23.444.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBenjamin Parker
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-11 02:35:39ID requested
12022-02-27 14:34:23announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: liver, NASH, secretome, hepatokines
Contact List
Benjamin Parker
contact affiliationThe University of Melbourne
contact emailben.parker@unimelb.edu.au
lab head
Benjamin Parker
contact affiliationThe University of Melbourne
contact emailben.parker@unimelb.edu.au
dataset submitter
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Dataset FTP location
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PRIDE project URI
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