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PXD024661

PXD024661 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA PROTAC Targets Splicing Factor 3B1
DescriptionThe proteolysis-targeting chimera (PROTAC) is a new technology to degrade a target protein. However, its clinical application is limited currently by lack of chemical binders to target protein. For instance, it is still unknown, whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs. We recently identified a 2-aminothiazole derivative (herein O4I2) to promote the generation of human pluripotent stem cells. In the present work, proteomic analysis on the biotinylated O4I2 revealed that O4I2 targeted SF3B1 and positively regulated RNA splicing.
HostingRepositoryPRIDE
AnnounceDate2022-08-08
AnnouncementXMLSubmission_2022-08-08_07:04:13.373.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGeorg Tascher
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-11 02:19:51ID requested
12022-08-08 07:04:14announced
Publication List
Gama-Brambila RA, Chen J, Zhou J, Tascher G, M, ΓΌ, nch C, Cheng X, A PROTAC targets splicing factor 3B1. Cell Chem Biol, 28(11):1616-1627.e8(2021) [pubmed]
Keyword List
submitter keyword: HeLa, TMTpro, PROTAC, Orbitrap LUMOS
Contact List
Xinlai Cheng
contact affiliationBuchmann Institute for Molecular Life Sciences, Pharmaceutical Chemistry, Goethe-University Frankfurt am Main,Max-von-Laue-Strasse 15. R. 3.652, D-60438 Frankfurt amMain, Germany
contact emailcheng@pharmchem.uni-frankfurt.de
lab head
Georg Tascher
contact affiliationInstitute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany
contact emailtascher@med.uni-frankfurt.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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