PXD024661 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A PROTAC Targets Splicing Factor 3B1 |
Description | The proteolysis-targeting chimera (PROTAC) is a new technology to degrade a target protein. However, its clinical application is limited currently by lack of chemical binders to target protein. For instance, it is still unknown, whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs. We recently identified a 2-aminothiazole derivative (herein O4I2) to promote the generation of human pluripotent stem cells. In the present work, proteomic analysis on the biotinylated O4I2 revealed that O4I2 targeted SF3B1 and positively regulated RNA splicing. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-08 |
AnnouncementXML | Submission_2022-08-08_07:04:13.373.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Georg Tascher |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-11 02:19:51 | ID requested | |
⏵ 1 | 2022-08-08 07:04:14 | announced | |
Publication List
Gama-Brambila RA, Chen J, Zhou J, Tascher G, M, ΓΌ, nch C, Cheng X, A PROTAC targets splicing factor 3B1. Cell Chem Biol, 28(11):1616-1627.e8(2021) [pubmed] |
Keyword List
submitter keyword: HeLa, TMTpro, PROTAC, Orbitrap LUMOS |
Contact List
Xinlai Cheng |
contact affiliation | Buchmann Institute for Molecular Life Sciences, Pharmaceutical Chemistry, Goethe-University Frankfurt am Main,Max-von-Laue-Strasse 15. R. 3.652, D-60438 Frankfurt amMain, Germany |
contact email | cheng@pharmchem.uni-frankfurt.de |
lab head | |
Georg Tascher |
contact affiliation | Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany |
contact email | tascher@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD024661 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024661
- Label: PRIDE project
- Name: A PROTAC Targets Splicing Factor 3B1