PXD024632

PXD024632 is an original dataset announced via ProteomeXchange.

Title	Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
Description	3D spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. However, the 3D spheroids are maintained under different conditions, with possible cofounding results. Here we performed an in-depth analysis of how various culture conditions influence 3D spheroids. Our aim was to find optimal conditions for the maintenance of a normal PHH phenotype.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-16_17:22:20.826.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Niklas Handin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-10 02:21:11	ID requested
⏵ 1	2022-02-16 17:22:21	announced

Handin N, Mickols E, Ö, lander M, Rudfeldt J, Blom K, Nyberg F, Senkowski W, Urdzik J, Maturi V, Frykn, ä, s M, Artursson P, Conditions for maintenance of hepatocyte differentiation and function in 3D cultures. iScience, 24(11):103235(2021) [pubmed]

submitter keyword: Primary Human Hepatocyte culture, LC-MS/MS,

Per Artursson
contact affiliation	Department of Pharmacy, Uppsala University, SE-75123 Uppsala
contact email	Per.Artursson@farmaci.uu.se
lab head
Niklas Handin
contact affiliation	Uppsala University, Department of Pharmacy, Drug Delivery
contact email	Niklas.Handin@farmaci.uu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD024632

PRIDE project URI

• PRIDE
  1. PXD024632
     1. Label: PRIDE project
     2. Name: Conditions for maintenance of hepatocyte differentiation and function in 3D cultures