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PXD024607 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDiscovery of Thymosin beta-4 as a human exerkine and growth factor
DescriptionSkeletal muscle has emerged as an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Via MS-based proteomics, we identified thymosin beta-4 (TMSB4X) to be the most upregulated secreted protein in the media of contracting C2C12 myotubes. TMSB4X was also acutely increased in the plasma of exercising humans and there was a net uptake of TMSB4X across the thigh during exercise. Chronic treatment of TMSB4X in mice did not ameliorate the metabolic disruptions associated with diet induced-obesity, nor did it enhance muscle regeneration in vivo. However, TMSB4X did increase osteoblast proliferation and neurite outgrowth, consistent with its WADA-classification as a prohibited growth factor. Thus, we report TMSB4X as a novel human exerkine with a potential role in cellular crosstalk.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitteratul shahaji deshmukh
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-09 05:32:19ID requested
12021-09-15 05:52:13announced
Publication List
Gonzalez-Franquesa A, Stocks B, Borg ML, Kuefner M, Dalbram E, Nielsen TS, Agrawal A, Pankratova S, Chibalin AV, Karlsson HKR, Gheibi S, Björnholm M, Jørgensen NR, Clemmensen C, Hostrup M, Treebak JT, Krook A, Zierath JR, Deshmukh AS, Discovery of thymosin β4 as a human exerkine and growth factor. Am J Physiol Cell Physiol, 321(5):C770-C778(2021) [pubmed]
Keyword List
submitter keyword: myokine, secreted factor, contraction, exercise, growth factor
Contact List
Atul Shahaji Deshmukh
contact affiliationNovo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Denmark.
contact emailatul.deshmukh@sund.ku.dk
lab head
atul shahaji deshmukh
contact affiliationCopenhagen University
contact emailatul.deshmukh@cpr.ku.dk
dataset submitter
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