PXD024568

PXD024568 is an original dataset announced via ProteomeXchange.

Title	Tau 315-441 Relative Quantification by Label-free Mass Spectrometry
Description	One of the main post-translational modifications which tau protein undergoes during neurodegeneration is its endogenous proteolysis, with two truncations described at carboxyl terminal domain (Asp421 and Glu391 truncations). Using in vitro cell models, it has been found that the expression of these truncated tau species produces morphological and functional alterations on different intracellular organelles. Recently a third truncation at carboxyl terminal of tau was described in the neuropathology by Caspase-2 proteolysis at Asp314 residue; however, its possible cytotoxic effects are still unknown. In the present project, the plasmids for Tau 315-441 were generated and expressed in the SH-SY5Y neuronal cell line to evaluate their endogenous protein expression by mass spectrometry. Tau 315-441 induced under-expression of proteins and altering membrane and nuclear proteins expression that participate in signalling pathways, control of the cell cycle and repair of the DNA.
HostingRepository	PRIDE
AnnounceDate	2026-09-05
AnnouncementXML	Submission_2026-09-05_07:27:02.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yadira Ivonne López Aviña
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-07 23:44:39	ID requested
⏵ 1	2026-09-05 07:27:03	announced

10.1016/J.EJCB.2026.151567;

submitter keyword: Truncated tau, neuroblastoma cells, neuroproteomics

Francisco García-Sierra
contact affiliation	Department of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. Instituto Politécnico Nacional 2508, CP 07360 Ciudad de México (CDMX), México. Tel.: +52 55 5747 3354
contact email	fgarcia-sierra@cell.cinvestav.mx
lab head
Yadira Ivonne López Aviña
contact affiliation	Department of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN)
contact email	yadira.ivonne.l.a@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD024568

PRIDE project URI

• PRIDE
  1. PXD024568
     1. Label: PRIDE project
     2. Name: Tau 315-441 Relative Quantification by Label-free Mass Spectrometry