PXD024549

PXD024549 is an original dataset announced via ProteomeXchange.

Title	Serum quantitative proteomics identifies prognostic biomarkers and physiological processes related to COVID-19 symptomatology
Description	The coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) posts a challenge for the understanding of factors affecting disease severity and the identification of prognostic biomarkers and physiological processes relevant for the development of new diagnostic and therapeutic interventions to contribute to the control of this pandemic. To address this challenge, in this study we used a quantitative proteomics together with multiple data analysis algorithms to characterize serum protein profiles in five cohorts from healthy to SARS-CoV-2-infected asymptomatic, recovered, nonsevere and severe individuals. The results corroborated previous findings, but the analysis was focused on novel disease processes and biomarkers. Our results contributed to the characterization of SARS-CoV-2-host molecular interactions and provided protein prognostic biomarkers and physiological disorders associated with COVID-19 with potential implications for the development of new diagnostic and therapeutic interventions to contribute to the control of this pandemic.
HostingRepository	PRIDE
AnnounceDate	2021-11-03
AnnouncementXML	Submission_2021-11-03_03:14:15.308.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024549
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Margarita Villar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-05 03:38:16	ID requested
⏵ 1	2021-11-03 03:14:16	announced

Villar M, Urra JM, Rodr, í, guez-Del-R, í, o FJ, Artigas-Jer, ó, nimo S, Jim, é, nez-Collados N, Ferreras-Colino E, Contreras M, de Mera IGF, Estrada-Pe, ñ, a A, Gort, á, zar C, de la Fuente J, Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 Symptomatology. Front Immunol, 12():730710(2021) [pubmed]

ProteomeXchange project tag: Covid-19

submitter keyword: SWATH-MS, human serum, COVID-19

Margarita Villar
contact affiliation	SaBio IREC (CSIC-UCLM-JCCM) Biochemistry UCLM
contact email	margaritam.villar@uclm.es
lab head
Margarita Villar
contact affiliation	University of Castilla- La Mancha
contact email	margaritam.villar@uclm.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD024549

PRIDE project URI

• PRIDE
  1. PXD024549
     1. Label: PRIDE project
     2. Name: Serum quantitative proteomics identifies prognostic biomarkers and physiological processes related to COVID-19 symptomatology