PXD024505

PXD024505 is an original dataset announced via ProteomeXchange.

Title	Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
Description	Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1 and MET, thereby unveiling a mechanism for specific overexpression of the key oncogenes in TNBC. We also identify ANLN as a novel TNBC-specific gene regulated by super-enhancer. Our studies reveal a TNBC-specific epigenomic landscape, contributing to the dysregulated oncogene expression in breast tumorigenesis.
HostingRepository	iProX
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2023-02-19_23:39:50.970.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liang Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-03 20:06:24	ID requested
⏵ 1	2023-02-19 23:39:51	announced

Huang H, Hu J, Maryam A, Huang Q, Zhang Y, Ramakrishnan S, Li J, Ma H, Ma VWS, Cheuk W, So GYK, Wang W, Cho WCS, Zhang L, Chan KM, Wang X, Chin YR, Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Nat Commun, 12(1):2242(2021) [pubmed]

submitter keyword: Super-enhancer， TNBC

Liang Zhang
contact affiliation	City University of Hong Kong
contact email	liangzhang.28@cityu.edu.hk
lab head
Liang Zhang
contact affiliation	City University of Hong Kong
contact email	liangzhang.28@cityu.edu.hk
dataset submitter

iProX dataset URI