PXD024452
PXD024452 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation |
| Description | We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283. |
| HostingRepository | iProX |
| AnnounceDate | 2021-03-01 |
| AnnouncementXML | Submission_2023-02-19_23:42:24.672.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bing Shan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-03-01 20:20:50 | ID requested | |
| 1 | 2021-03-01 20:21:30 | announced | |
| ⏵ 2 | 2023-02-19 23:42:25 | announced | 2023-02-20: Update publication information. |
Publication List
| Wu Y, Zhang C, Liu X, He Z, Shan B, Zeng Q, Zhao Q, Zhu H, Liao H, Cen X, Xu X, Zhang M, Hou T, Wang Z, Yan H, Yang S, Sun Y, Chen Y, Wu R, Xie T, Chen W, Najafov A, Ying S, Xia H, ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation. Nat Commun, 12(1):2346(2021) [pubmed] |
Keyword List
| submitter keyword: PDL1 phosphorylation |
Contact List
| Hongguang Xia | |
|---|---|
| contact affiliation | The First Affiliated Hospital, and Department of Biochemistry, Zhejiang University School of Medicine |
| contact email | hongguangxia@zju.edu.cn |
| lab head | |
| Bing Shan | |
| contact affiliation | Shanghai institute of Organic Chemistry,CAS |
| contact email | shanbing@sioc.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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