PXD024434

PXD024434 is an original dataset announced via ProteomeXchange.

Title	Proteomic signature of plasma-derived exosomes in different stages of melanoma patients.
Description	Exosomes, extracellular vesicles of 30-150 nm, are released by normal and tumor cells. These nanovesicles play a major role in cell communication and can be found in biological fluids as carriers of biomarkers. Tumor exosomes can inhibit immune responses, mediate drug resistance and transform mesenchymal stem cells. In contrast to healthy donors, cancer patients’ plasma contain higher levels of exosomes. Cutaneous melanoma is a very aggressive cancer whose incidence has rapidly increased worldwide and the prognosis is generally poor, given the propensity of melanoma cells to spread to distant sites while evading immune system control.We investigated potential differences between plasma exosomes derived from healthy donors (HD) and melanoma patients at 0-I, II, and III-IV stages of disease.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:45:38.050.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marialuisa Casella
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-01 06:09:41	ID requested
1	2023-05-08 17:57:55	announced
⏵ 2	2023-11-14 08:45:45	announced	2023-11-14: Updated project metadata.

Paolino G, Huber V, Camerini S, Casella M, Macone A, Bertuccini L, Iosi F, Moliterni E, Cecchetti S, Ruspantini I, Chiarotti F, Vergani E, Lalli L, Raggi C, Di Biase A, Calvieri S, Mercuri SR, Lugini L, Federici C, The Fatty Acid and Protein Profiles of Circulating CD81-Positive Small Extracellular Vesicles Are Associated with Disease Stage in Melanoma Patients. Cancers (Basel), 13(16):(2021) [pubmed]

submitter keyword: exosomes, proteomics,melanoma

Serena Camerini Luisa Casella
contact affiliation	Italian Intitute of Health
contact email	serena.camerin@iss.it
lab head
Marialuisa Casella
contact affiliation	Istituto Superiore di Sanità
contact email	marialuisa.casella@iss.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD024434

PRIDE project URI

• PRIDE
  1. PXD024434
     1. Label: PRIDE project
     2. Name: Proteomic signature of plasma-derived exosomes in different stages of melanoma patients.