PXD024418

PXD024418 is an original dataset announced via ProteomeXchange.

Title	Expression Signature and Regulatory Role of miRNAs in Hepatocellular Carcinoma-Induced Cancer Associated Fibroblasts
Description	The study aims to assess the influence of soluble factors from HCC on MSCs and to investigate the regulatory effect of miRNAs in human adipose- MSCs (hA-MSCs) cultured in HCC microenvironment.The results suggest an interaction between tumor cells and the surrounding stromal components and provide evidence to the direct generation of CAF phenotype upon exposure of hA-MSCs to Huh-7 cancer microenvironment, favoring cancer progression. This might shed the light on the fate of hA-MSCs use in therapy in HCC. hA-MSCs modulation may be achieved via dysregulation of miR17-5P and 615-5p expression. These data suggest that miRNAs may present a new target for HCC treatment.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:52:11.563.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024418
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ali Anwar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600+

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-28 23:05:59	ID requested
1	2022-04-19 04:21:00	announced
⏵ 2	2023-11-14 08:52:12	announced	2023-11-14: Updated project metadata.

10.6019/PXD024418;

submitter keyword: Human, LC-MSMS, Hepatocellular Carcinoma

Sameh Magdeldin
contact affiliation	Proteomics and metabolomics unit, Basic research department, Children's Cancer Hospital, 57357 Cairo, (CCHE-57357), Egypt
contact email	sameh.magdeldin@57357.org
lab head
Ali Anwar
contact affiliation	Proteomics and metabolomics unit, Basic research department, Children's Cancer Hospital, 57357 Cairo, (CCHE-57357), Egypt
contact email	ali.anwar@57357.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD024418

PRIDE project URI

• PRIDE
  1. PXD024418
     1. Label: PRIDE project
     2. Name: Expression Signature and Regulatory Role of miRNAs in Hepatocellular Carcinoma-Induced Cancer Associated Fibroblasts