PXD024410

PXD024410 is an original dataset announced via ProteomeXchange.

Title	Distinct Molecular Signature of Asymptomatic COVID-19 Revealed by Lipidomic Characterization
Description	Asymptomatic infection has become one of the biggest challenges in controlling the spread of COVID-19. However, the rapid diagnosis and pathogenesis elucidation of the disease remain critical issues. Here, we performed comprehensive lipidomic profiling of 267 serum samples from 89 asymptomatic COVID-19 patients and 178 healthy controls. A panel of 15 key lipids was discovered that could high-efficiently distinguish asymptomatic patients by using a new ensemble learning model, which provided a high accuracy of 96.0% with only 3.6% false positive rate and 4.8% false negative rate. In addition, characteristic lipidomic changes revealed distinct dysregulated lipid metabolism upon asymptomatic SARS-CoV-2 infection, which implicated the specific host immune, inflammatory, and antiviral responses during the virus invasion in asymptomatic COVID-19. This study provides an effective method for the pre-diagnosis of asymptomatic COVID-19, and the revealed molecular signature provided clues for the pathogenesis and therapy of this disease.
HostingRepository	iProX
AnnounceDate	2022-06-14
AnnouncementXML	Submission_2023-02-20_19:17:40.204.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Suming Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-28 20:54:08	ID requested
1	2021-02-28 20:54:46	announced
2	2022-06-13 20:44:38	announced	2022-06-14: Update informaiton.
⏵ 3	2023-02-20 19:17:41	announced	2022-06-14: Update informaiton. 2023-02-21: Update information.

Chen M, Hao Y, Chen S, A protocol for investigating lipidomic dysregulation and discovering lipid biomarkers from human serums. STAR Protoc, 3(1):101125(2022) [pubmed]

submitter keyword: COVID-19, Asymptomatic, Lipidomics

Suming Chen
contact affiliation	The Institute for Advanced Studies, Wuhan University
contact email	chensm@iccas.ac.cn
lab head
Suming Chen
contact affiliation	The Institute for Advanced Studies, Wuhan University
contact email	chensm@iccas.ac.cn
dataset submitter

iProX dataset URI