PXD024338

PXD024338 is an original dataset announced via ProteomeXchange.

Title	Defining changes in the steady-state levels of ubiquitinated peptides in aging and longevity
Description	We performed diGLY enrichment followed by label-free proteomics in C. elegans to define and quantify changes in the ubiquitinated (Ub)-proteome during the aging process. More specifically, we compared wild-type worms at the first day of adulthood with young (day 5), mid-age (day 10) and aged adults (day 15). Moreover, we assessed the Ub-modified proteome of age-matched long-lived genetic models of dietary restriction (eat-2(ad1116)) and reduced reduced insulin/IGF-1 signaling (daf-2(e1370)).
HostingRepository	PRIDE
AnnounceDate	2024-11-11
AnnouncementXML	Submission_2024-11-11_06:15:42.154.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Vilchez
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-24 02:14:32	ID requested
1	2021-05-27 01:00:09	announced
⏵ 2	2024-11-11 06:15:42	announced	2024-11-11: Updated project metadata.

Koyuncu S, Loureiro R, Lee HJ, Wagle P, Krueger M, Vilchez D, Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Nature, 596(7871):285-290(2021) [pubmed]

10.1038/s41586-021-03781-z;

submitter keyword: Ubiquitination,Aging, C. elegans

David Vilchez
contact affiliation	CECAD, University of Cologne
contact email	dvilchez@uni-koeln.de
lab head
David Vilchez
contact affiliation	University of Cologne
contact email	dvilchez@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/05/PXD024338

PRIDE project URI

• PRIDE
  1. PXD024338
     1. Label: PRIDE project
     2. Name: Defining changes in the steady-state levels of ubiquitinated peptides in aging and longevity