PXD024311
PXD024311 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| Description | Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quantification proteomics and untargeted metabolomics were used to screen disease-related signaling pathways through clustering and enrichment analysis of the differential expression of proteins and metabolites. The main imaging features were lesions located in the bilateral lower lobes and involvement in five lobes. The closed association pathways were FcγR-mediated phagocytosis, PPAR signaling, TRP-inflammatory pathways, and the urea cycle. Our results provide evidence for the detection of serum biomarkers and targeted therapy in patients with Covid-19. |
| HostingRepository | iProX |
| AnnounceDate | 2021-02-22 |
| AnnouncementXML | Submission_2022-09-19_00:02:51.368.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wensheng Lu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-02-22 19:56:32 | ID requested | |
| ⏵ 1 | 2022-09-19 00:02:52 | announced |
Publication List
| Yang J, Chen C, Chen W, Huang L, Fu Z, Ye K, Lv L, Nong Z, Zhou X, Lu W, Zhong M, Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis. Sci Rep, 11(1):14601(2021) [pubmed] |
Keyword List
| submitter keyword: Covid-19, pulmonary fibrosis, proteomics, metabonomics |
Contact List
| Wensheng Lu | |
|---|---|
| contact affiliation | People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, P. R. China |
| contact email | 40192385@qq.com |
| lab head | |
| Wensheng Lu | |
| contact affiliation | People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, P. R. China |
| contact email | 40192385@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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