PXD024309

PXD024309 is an original dataset announced via ProteomeXchange.

Title	Profiling of Proteome and Ubiquitome Changesin in endothelial cells in response to shear stress
Description	Shear stress generated by flowing blood has major effects on vascular function. Bends and branches of arteries are exposed to complex blood flow patterns, a mechanical environment that promotes cardiovascular dysfunction and atherosclerosis. The exact mechanisms, by which endothelial cells translate shear stress to physiological and pathophysiological responses remain incompletely understood. Here, we identified perturbations of the ubiquin landscape in endothelial cells driven by shear stress. The integrative analysis of proteome and ubiquitome revealed that non-degradative ubiquitination controls cytoskeleton rearrangements in response to shear stress. These results provide a global view of the contribution of the ubiquitin system during shear stress response.
HostingRepository	PRIDE
AnnounceDate	2025-05-23
AnnouncementXML	Submission_2025-05-23_06:34:26.697.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Delphi Van Haver
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-22 08:25:45	ID requested
⏵ 1	2025-05-23 06:34:27	announced

10.1002/ADVS.202303367;

submitter keyword: endothelial cells, ubiquitome,Shear stress, proteome

Anna Sablina
contact affiliation	VIB-KU Leuven Center for Cancer Biology
contact email	anna.sablina@kuleuven.be
lab head
Delphi Van Haver
contact affiliation	VIB Proteomics Core
contact email	delphi.vanhaver@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD024309

PRIDE project URI

• PRIDE
  1. PXD024309
     1. Label: PRIDE project
     2. Name: Profiling of Proteome and Ubiquitome Changesin in endothelial cells in response to shear stress