PXD024304

PXD024304 is an original dataset announced via ProteomeXchange.

Title	Proteomic and pathway profiling of four Breast Cancer cell lines.
Description	Biomarker discovery in breast cancer (BC) is a clinical need for therapeutics and non-invasive diagnostics. In a single study, we provide a comparative differential proteomic profile of four invasion, metastasis, angiogenesis and drug resistance. Exosome proteome profile reflects their different BC cell origin suggesting potential indicators of BC subtype. Further, our pathway inference analysis reveals a differential role of exosomes in BC signalling pathways in recipient cells, according to their protein cargo and cell origin. Our results may significantly contribute to further studies for the design of BC biomarker predictor to stratify BC patients and the development of novel therapeutic strategies.BC cell lines and their derived- exosomes, representative of the most relevant BC subtypes in clinic. Differentially-expressed proteins, in both cells and exosomes, include indicators of
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:51:37.980.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luz Valero
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-22 06:34:52	ID requested
⏵ 1	2024-10-17 02:51:38	announced

10.1007/s00018-024-05403-z;

Andreu Z, Hidalgo MR, Masi, á E, Romera-Giner S, Malmierca-Merlo P, L, ó, pez-Guerrero JA, Garc, í, a-Garc, í, a F, Vicent MJ, Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes. Cell Mol Life Sci, 81(1):363(2024) [pubmed]

submitter keyword: Biomarker discovery, breast cancer, exosomes, Differentially-expressed proteins, proteomic profile

María Jesús Vicent, Francisco García García
contact affiliation	Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, 46012 Valencia, Spain
contact email	fgarcia@cipf.es
lab head
Luz Valero
contact affiliation	Universitat de Valencia
contact email	mluz.valero@uv.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD024304

PRIDE project URI

• PRIDE
  1. PXD024304
     1. Label: PRIDE project
     2. Name: Proteomic and pathway profiling of four Breast Cancer cell lines.