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PXD024278

PXD024278 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTandem mass tag-based quantitative proteomics analysis of chicken bursa of Fabricius infected with reticuloendotheliosis virus
DescriptionReticuloendotheliosis virus (REV) is a type C avian retrovirus; which causes immunosuppression, dwarf syndrome, and lymphoma in infected hosts. In this study, we used tandem mass tag (TMT) labeling and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) to characterize protein alterations in chicken bursa of Fabricius, before and after REV infection at 7, 14, 21, and 28 days. Our data showed that 1127, 999, 910 and 1138 differentially expressed proteins were significantly altered at 7, 14, 21, 28 days after REV infection, respectively. Bioinformatics analysis indicated these proteins were mainly participate in are mainly involved with immune responses, energy metabolism, cellular processes, biological regulation, metabolic processes, response to stimuli, and multicellular organismal process. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway cluster analysis showed that post-infection, proteins were enriched in the cell cycle, Wnt signaling, antigen processing and presentation, cytokine receptor interaction, Adenosine 3',5'-cyclic monophosphate signaling pathway, and NF-κB signaling. In addition, heat shock protein (HSP) levels also changed significantly after REV infection. These findings help clarify interactions between REV and the host, and provides mechanistic insights on REV-induced host immunosuppression.
HostingRepositoryPRIDE
AnnounceDate2022-02-16
AnnouncementXMLSubmission_2022-02-16_15:51:44.605.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShimin Zheng
SpeciesList scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-02-22 00:21:42ID requested
12022-02-16 15:51:45announced
Publication List
Yang D, Lv X, Zhang S, Zheng S, Tandem Mass Tag-Based Quantitative Proteomic Analysis of Chicken Bursa of Fabricius Infected With Reticuloendotheliosis Virus. Front Vet Sci, 8():666512(2021) [pubmed]
Keyword List
submitter keyword: Reticuloendotheliosis virus
bursa of Fabricius
quantitative proteomics
differentially expressed proteins
Contact List
Shimin Zheng
contact affiliationNortheast Agricultural University, China
contact emailzhengshiminbl@sohu.com
lab head
Shimin Zheng
contact affiliationNortheast Agricultural University
contact emailzhengshiminbl@sohu.com
dataset submitter
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Dataset FTP location
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