PXD024271

PXD024271 is an original dataset announced via ProteomeXchange.

Title	Urinary proteomics investigations into contrast-induced acute kidney injury
Description	The incidence of CI-AKI varies from 5% to 20% among hospitalized patients. However, research on the pathophysiological mechanism and biomarkers of CI-AKI has not been deep so far, especially research with LC-MS/MS methods. MS has brought proteomics research into the modern era and continues to be the best choice for accurate medicine. Thus, we identified the urine proteins of CI-AKI patients with LC-MS/MS methods and compared the differences in urine protein expression between CI-AKI patients and non-CI-AKI patients with bioinformatics analysis. Several DEPs were identified in CI-AKI patients, some of which are related to kidney diseases, including annexin A2 (ANXA2), growth differentiation factor 15 (GDF15) and retinol-binding protein 4 (RBP4). We think that they are likely to be biomarkers of CI-AKI. Among the DEPs, we found that the number and degree of proteins expressed in tubules were more significant than those in glomeruli, which indicated that tubule injury may play a more important role in CI-AKI. Through bioinformatics analysis, we found that the immune response and inflammation were involved in CI-AKI, which indicated that the immune system and inflammatory response may participate in CI-AKI progression. Our study revealed some proteins that are likely to be biomarkers and provided a further understanding of CI-AKI.
HostingRepository	iProX
AnnounceDate	2021-02-21
AnnouncementXML	Submission_2023-02-19_23:44:36.102.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuai Han
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-21 20:42:22	ID requested
1	2021-02-21 20:42:55	announced
⏵ 2	2023-02-19 23:44:37	announced	2023-02-20: Update publication information.

Zhu H, Chu W, Han S, Gao B, Wang X, Urinary proteomics investigations into contrast-induced acute kidney injury. PLoS One, 16(10):e0258736(2021) [pubmed]

submitter keyword: CI-AKI, urine proteins, proteomics, biomarkers, bioinformatics analysis

Shuai Han
contact affiliation	Affiliated Zhongshan Hospital of Dalian University
contact email	87564385@qq.com
lab head
Shuai Han
contact affiliation	Affiliated Zhongshan Hospital of Dalian University
contact email	87564385@qq.com
dataset submitter

iProX dataset URI